Therapeutic antimicrobial peptides may compromise natural immunity
نویسندگان
چکیده
منابع مشابه
Therapeutic antimicrobial peptides may compromise natural immunity.
Antimicrobial peptides (AMPs) have been proposed as a promising new class of antimicrobials despite warnings that therapeutic use could drive the evolution of pathogens resistant to our own immunity peptides. Using experimental evolution, we demonstrate that Staphylococcus aureus rapidly evolved resistance to pexiganan, a drug-candidate for diabetic leg ulcer infections. Evolved resistance was ...
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Copyright © 2012 Mathew Upton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In developing this special issue, we sought to raise awareness of the potential of antimicrobial peptides (AMPs) for clinical use and to highligh...
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ژورنال
عنوان ژورنال: Biology Letters
سال: 2012
ISSN: 1744-9561,1744-957X
DOI: 10.1098/rsbl.2011.1203